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Email Address. Explore Apps. About About Drugs. You can see that the 50mcg dosage does not have any extra dyes, so if you can't switch medications from levothyroxine to Tirosint due to price or some other reason , it would be worth a trial of switching to a 50mcg dose. If you are on mcg of Levothyroxine then using 2. This may require that you take more than 1 tablet, but it's worth the price if you start to feel better. No nothing is ever that easy! One important point I want to expand on is the implication that gastrointestinal problems have on thyroid hormone and other nutrients.

Hypothyroid patients yes even those already on thyroid medications but still with symptoms are in a tricky situation. This general lack of stomach acid can also worsen or create other intestinal problems which make absorption even worse. It's worth taking some time to point out that replacing thyroid hormone doesn't necessarily reverse these conditions and taking extra steps to treat these GI problems if present will be necessary for many patients.

This is only true if your body has no issues with the conversion process of T4 to T3 and if your problem with levothyroxine was a lack of absorption. If the change from Levothyroxine to Tirosint results in an overall increase in thyroid hormone in the body, and the conversion of T4 to T3, then yes, Tirosint may result in weight loss. This makes the huge assumption that your body has no issues with converting T4 to T3 and this is a very big assumption to make. You can read more about why levothyroxine can actually contribute to weight gain here , and you can read more about how to use Synthroid and levothyroxine for weight loss properly here.

This is probably the best way to use Tirosint and this is how I use it effectively in my practice. Tirosint by itself usually results in a reduction of overall hypothyroid symptoms due to superior absorption, but this effect is multiplied by the addition of T3 containing thyroid medications like Cytomel or liothyronine. Other thyroid hormones and medications can safely be added to Tirosint, but remember that general rules for taking thyroid hormone still apply.

That means don't take Tirosint with food, avoid taking supplements or vitamins at the same time as Tirosint and so on. Tirosint is still a T4 only thyroid medication and using this medication fits into the current paradigm of thyroid treatment however flawed this paradigm might be. Compare that to trying to get your provider to switch you to NDT, which is infinitely more difficult.

Nowadays it's also becoming more commonplace for providers to add lower dosages of T3 to T4 thyroid doses. While both contain equivalent dosages and concentrations of thyroid hormone, some patients do find that switching over may result in almost hyperthyroid like symptoms. In my opinion, this results from increased absorption and a flush of thyroid hormone into the body.

If this does occur in you, simply slightly reducing the dose is usually enough to control these symptoms.

Tirosint vs Levothyroxine: The Case for Switching Thyroid Medication

The bottom line is that many patients stand to benefit from switching to Tirosint from Levothyroxine or Synthroid and even other forms of thyroid medications. This improvement is felt to be due to increased and superior absorption in addition to a reduction in symptoms related to inactive ingredients. Remember that Tirosint has 1 active ingredient and 3 inactive ingredients making it the "cleanest" thyroid hormone medication.

Tirosint vs Levothyroxine - The case for Switching Thyroid Medication

Special interest should be taken in certain patients with gastrointestinal symptoms as these patients tend to have low stomach acid and other nutrient deficiencies. Another huge benefit of Tirosint is that this medication fits the current thyroid treatment paradigm and because of this many providers are more willing to prescribe this medication over other formulations. At the end of the day, you are a unique patient and it may take a combination of time and trial and error to find your optimal dose, but don't give up! With persistence, you will get there. Below I've also included some frequently asked questions that I receive from patients regarding Tirosint.

You can use this list if you don't feel that your questions or concerns were answered in the information above. If you have any other questions or comments please don't hesitate to leave them in the comment section below as I check these frequently and I want to keep the conversation going.

Medications that are T4 only thyroid medication include Levothyroxine , Synthroid , Tirosint, and Levoxyl. In my experience, I've found that most people do subjectively experience a reduction in hypothyroid symptoms when switching to Tirosint even when switching from levothyroxine to Tirosint or Synthroid to Tirosint at the same dose.

That doesn't mean it will work for you, but it's certainly worth a month trial in most cases, especially if you don't feel well on your current regimen.

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When trying to optimize and reduce your symptoms it's important to take into account other factors like T4 to T3 conversion, inflammation, and other hormone imbalances. These other factors may be playing a role in why you are or aren't doing well on your current regimen. Like other T4 only thyroid medications , Tirosint can potentially and indirectly lead to weight gain. This usually occurs from improper thyroid conversion and the production of too much reverse T3.

Recall that reverse T3 is the antithyroid metabolite and directly competes for binding and cellular activation with T3. The more reverse T3 you have in your body the more likely you are to experience hypothyroid like symptoms even with a normal or low TSH. Many patients on T4 only thyroid medications also may experience a condition known as low T3 syndrome which is felt to be due to a variety of reasons including lack of thyroid conversion though this condition doesn't always have high levels of reverse T3.

Like other thyroid hormone medications , Tirosint should be taken on an empty stomach in the early morning. You should also avoid supplements and the intake of food for at least 60 minutes after taking it. These studies show that taking Tirosint in the morning with food does not impact its absorption.


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Tirosint can and should be considered, in cases where you may be experiencing nausea when taking your thyroid medication on an empty stomach. Even though it can be taken with food doesn't necessarily mean that you should take it with food, but it's certainly worth considering in certain situations. Yes, Tirosint can safely be combined with other thyroid hormone medications.

Is Tirosint A Better Option Than Synthroid?

If you are taking vitamins or minerals then it's best to consume these supplements minutes after you take your medication. It's also best to avoid taking Tirosint directly with supplements which contain iron or calcium as these may directly bind up the active thyroid hormone. You can see a list of other substances which interfere with thyroid hormone absorption here.

Like other thyroid hormone medications Tirosint if used in high doses can result in hyperthyroid like symptoms:. These would be considered adverse or serious side effects and if you experience any of these you should seek medical care as soon as possible. This doesn't mean that you can't or won't experience any negative side effects from this medication, but it does mean that the chance of this happening is low.

Any minor symptoms associated with using Tirosint are usually self-limiting which means they tend to resolve on their own within a few weeks. If you are ever worried about a side effect you feel is related to your medication then it's best to contact the doctor who prescribed the medication for you. Believe it or not, Tirosint is one of the only thyroid medications that CAN be taken with food and even with coffee.

As you probably know, thyroid patients are told that they should take thyroid medication on an empty stomach and avoid eating or taking supplements for at least 1 hour afterward. While this rule technically still applies for Tirosint, some studies have shown that eating food right after taking it, and even drinking coffee while you take it, do not alter how much is absorbed into your body.

While I typically don't recommend drinking coffee before you take your thyroid medication, this might be an alternative for those people with schedules that don't really allow for a 1-hour rest after eating or right after waking up. If you take levothyroxine or Synthroid, you should absolutely avoid coffee when taking your medication. Drinking coffee can speed up your intestinal tract from the caffeine and reduce thyroid hormone absorption. Because Tirosint is a newer formulation of T4 thyroid medication the price tends to be more expensive than other generic brands.

You can see a list of cash prices below using goodrx. You can use goodrx. If your insurance won't cover the cost and if the cash price is too high you still have one last option:. You can find more information about the coupons here. Westin Childs is a Doctor of Osteopathic Medicine. He provides well-researched actionable information about hormone-related disorders and formulates supplements to treat these disorders.

His focus is on managing thyroid disorders, weight loss resistance, and other sex hormone imbalances. You can read more about his own personal journey here.


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  5. The most important thing you should focus on is trying to find someone local to help guide you through this process. I have taken synthroid and cytomel and switched about 3 years ago to naturethyroid. My labs have always been pretty lackluster — low in the range, or below.

    Lost weight, more energy, etc. Hi Dr Westin, I am on 90 mg armour, and want to switch to WP thyroid as I have some gluten issues hashis but just read up on tirosint! Perhaps i should try the tirosint? The price has steadily increased since then. Same product and same packaging.

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    Thank you. Thyroid medications are very personal and what you need will be different than what other people need. My biggest complaint has been my hair loss.

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